The #1 reason I would tell you not to buy a large gas powered boat is resale, or really, the lack thereof. A gaser will always be a harder and slower sale and price will lag behind diesels when it comes time to sell. Fuel burn is terrible at anything beyond hull speed. My previous boat was a 2005 Silveryon 38 Sport Bridge- nice boat, fancy, lots of room, etc. She was powered with twin 8.1 Crusader High Outputs (425hp each). At hull speed I averaged around 5-6 GPH so really not bad. If I put her up on plane I could easily burn 50 GPH. I do not miss that boat though we sure had fun on her. Now, if you get a houseboat, gasers are acceptable. If you get an express cruiser, gasers at 34-35 are ok. I would not want gasers in an aft cabin or sedan. Typically speaking the biggest reason to go for gasers instead of diesel was the big difference in purchase price between the two. The economy and market have equalized that out so most times you can get a diesel powered boat for the price the same boat with gasers is selling for so go diesel.
The flip side of that debate is if you are getting a high output, turbo, high HP diesel, you can sure do a LOT of very expensive damage to them very quickly and you will pay dearly for those repairs. Gas engines are almost throw away type deal and can put new ones in for like $10-12k each so not a deal killer if you fry a motor.
Having owned both though I can tell you I don't ever see myself owning a gas powered large boat again. Beyond safety, resele, etc. you also have the much better performance of diesels, especially for docking in close quarters.