Welcome to TF!
I spent close to 5-years delivering boats out of San Francisco. 80% of my runs were northbound from SoCal to PNW to escape California sales taxes.
I have a slightly different perspective.
First, April may not have the highest wind, but it is the most consistently windy month of the year. It can blow 20-25 knots out of the N/NW for days on end which really builds seas. Tough to make north bound progress. In May, summer pattern starts to kick-in. Winds are calm in the morning (sometimes a short blow early morning, shortly after sunrise). By about 9am, a breeze starts to fill-in. Small white caps start to form at around 17-kts of breeze - if these form before about 11AM, it will be a long day. If after 1PM, will be a great day.
Winds build to about 20-25 kts by late afternoon which brings 4-5 foot short chop for a couple hours. I used to move closer to the beach which seemed to knock-down a fair amount of the chop. At sundown, the wind dies off and I'd move into deeper water to run at night to avoid crab traps.
With your speed, I'd run early and hopefully get someplace by lunchtime if possible (which it may not be). For example, stopping into Morro Bay reqires some planning for high tide an slack current.
I tried to plan rounding Pt Conception/Arguello around midnight. I still got spanked a couple times, but was much better than late afternoon. Cojo anchorage is workable to stage departure.
So to answer your question, if you wait for a full day of calm winds, you might have to wait until October. But with some patience and a wee bit of courage, you'll figure out the weather rhythm of the west coast. You can usually manage to keep bumpy weather down to a few hours in the afternoon.
Good luck - congrats on impending retirement. Very exciting!!!
Peter