First off, Welcome to the Forum!
We RV'd for about 11 years, but not full time. Most was about 6 months out of 12. First in a 27' Travel Trailer (TT), then a 40' Dutchstar. The TT was more like camping, but the Dutchstar was living large!
Now we're in a boat. We've been full time cruisers for the past 2 years. Bought the boat in WA State, cruised Puget Sound, and up as far North as Glacier Bay Alaska. We're currently in Mexico, slowly making our way over the Bahamas, East Coast, etc. much, Much, MUCH more comfortable in the boat than in the RV(s). Then again, we could relocate in the RV at 60 mph! And at 7.5 miles/gallon. The boat is 7 kts, and 2.5 nmpg.
One of the biggest problems you may run into is insurance. You will be going from a smaller boat, to a 50 - 60 footer . . . . and your experience is not easily documented, and not what they're going to want to see for a larger boat. AND you're not planning on relocating the boat (kids in school) North, out of the hurricane "belt" June thru November. . . . . not sure if you can even get insurance, let alone "affordable" insurance.
I'm 64 years old (as of today), and I wish we'd done this 15 years ago, rather than 2 years ago.
Your plan sounds wonderful, don't give up on it, but the logistics of it may be daunting at times. Best of luck in whatever you decide!