I would say it depends a lot on where you are running and how fast. Open water and out of shipping lanes would be different than the AICW. Overnight would be different than just a couple hours of darkness.
The most I've done is a couple hours before daybreak and I find this pretty tense and demanding compared to running in daylight. Others with more experience or an actual need to run at night may feel differently.
The last thread in which I responded to a similar question, after about 200 posts, I finally realized that I was answering the initial question based on being in the middle of the Atlantic, whereas others were answering as if going up the ICW.
So it all depends in where you are, how long you need to do it and your comfort level with running on instruments.
E.g. my radar is on whenever my running lights are on, which is whenever the engine is running. No matter how good the vsby, whenever another boat or object is nearby, I check it's return on the radar. Even running down the ICW, I'll set the radar target to the boat I am following or being followed by, just to see how the radar performs, practice my instrument running and fully understand the logic in its design.
Thus in fog or at night, I know what it's telling me AND what's it NOT telling me.
For me being in a narrow river or channel like the ICW is extremely stressful. A 10 hr day is a very long day. Evening or night, requires another person or two. 24/7 travel would require 4 crew.
Now, New England, Maine in particular, is virtually impossible at night or fog, no matter how many crew, due to the lobster pots that are everywhere, even worse Downeast AND the risk of failure is so high.
At least on the ICW, should you run off course, a soft, sandy bottom usually awaits. In New England, it's hard, nasty rocks.
Once a bit off shore, things get easier.
And as I've said, the middle of the ocean is a piece of cake.